The 25-year-old was forced off on a stretcher just before the hour mark after been injured in the build-up to Everton’s goal.
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Slot now has a major selection headache with first choice Alisson also sidelined and not expected to return until May.
Speaking to reporters after the game, Slot offered a worrying update, confirming that Mamardashvili was taken to hospital.
“He has gone off to hospital,” he said.
“It looked to me, and it is also what they told me, an open wound. It will not be a long-term injury, let's see if he will be available next week.”