Sesko, 22, put Man United 2-0 up with his 11th of the season as they beat Liverpool 3-2 at Old Trafford on Sunday (May 3).
It was controversial, however, with the ball appeared to ever so slightly graze his hand before it ended up in the back of the net.
Speaking to reporters after the game, Slot claimed it was just the latest in a long line of decisions that have gone against his side the season.
"If it was a touch (by Sesko) which I think it is -- in a ball sport it has a certain curve and it changes -- it must be a contact then we should have a debate is that enough to disallow a goal.
"I don't think it is a surprise to anyone this season that if there is a VAR intervention it goes against us. It has been the whole season the same."
"I remember PSG at home, getting a penalty for a soft touch on (Alexis) Mac Allister, VAR intervenes and it is not a pen," the Dutchman explained.
"The other week, PSG gets one. This time, the referee stops play when a United player is injured off the pitch, but last week played continues when our goalkeeper is on the floor needing treatment."