Sunday's 2-1 win for City over title rivals Arsenal moved Pep Guardiola's side to just three points off the Gunners with a game in hand.
City face Burnley on Wednesday night, a game they are firm favourites for as they seek to leapfrog The Gunners before the weekend fixtures.
Not only did Arsenal lose to City, but they dropped points to Bournemouth the week before and only managed a 0-0 result against Sporting in between.
Speaking to Stake, Aguero suggested that Arsenal may be struggling both physically and mentally as the final stage of the season really heats up.
“I don’t know if it’s that bad, but Arsenal are under huge pressure. They are top of the table, and it’s been many years since Arsenal last won the Premier League. Every team plays against them with extra motivation, and behind them is City who never forgive.
“There is a lot of anxiety and nerves. Sometimes when you want to do everything right you end up making mistakes. It’s normal - players want to do things perfectly and mentally they go faster than the game. I think it’s mostly mental.
“Arsenal play well; the only thing weighing on them is being at the top. Everything depends on Arteta’s experience from his time at City and the communication he can have with the players to help Arsenal become champions. They have to think game by game.”
Arsenal face Newcastle this weekend and are likely going to have to be perfect if they are to lift the title this season as City smell blood and remain hot on their heels.