Antony, after a successful loan for the second-half of last season, was signed permanently from Manchester United in the final days of the summer market.
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On a deal to 2030, Antony has a goal and assist in three games at Betis so far this season.
"I am 100 percent sure that Antony is perhaps the most important signing in Betis' history," Fajardo told PA Sport.
"Everything (with the signing), for the talent, the level of the player, the level of the club (Manchester United) - a big team, a big project, so I am 100 percent sure that Antony is the best signing in Betis' history."