City face the reigning champions at St James’ Park in the first of two semi-final legs in a game that will bring Newcastle confidence due to City’s defensive crisis which sees Ruben Dias, Josko Gvardiol and John Stones absent.
However, the Magpies also have a number of knocks that could leave Howe’s side exposed as they aim to build on wins against Bradford City, Tottenham Hotspur and Fulham.
Anthony Elanga and Jacob Murphy set for fitness tests, and Howe says they have a “possibility” of featuring tomorrow.
Fabian Schar (ankle ligament), Will Osula (ankle) remain out however, which does not help Howe who will be hoping to rotate his side to maintain fitness levels.
Emil Krafth (knee) Tino Livramento (hamstring) are out, whilst Dan Burn remains a “couple of weeks” away as he recovers from a lung and rib injury picked up at Sunderland last month.
The injuries leave Newcastle with just four fit senior defenders for Tuesday’s clash, meaning both sides will be weak defensively.
Howe's team has an impressive recent home record against City, winning twice, drawing once and losing once in the last four head-to-heads as he aims to continue that run this week.