The Gunners and the Hammers do battle in Sunday's Premier League derby at the London Stadium in a clash that is crucial for both the title race and relegation scrap.
After City beat Brentford 3-0 with goals from Jeremy Doku, Erling Haaland and Omar Marmoush on Saturday night, Arsenal lead at the top was cut to just 2 points in what is a nervy end to the campaign.
Guardiola needs a favour from Nuno Espírito Santo's side if their title chances are to stay alive in the final 3 games and the Spaniard has now jokingly asked for a favour from the side who are in the relegation zone.
The Spanish coach wrapped up his post-match press conference by making a crossed-arms gesture and saying “Come on you Irons” as he jokingly supported the side who could help hand him the title this season.
Title race is not in Man City's hands
Speaking further on the intense title race which could come down to the wire, Guardiola suggested that there was nothing City could do except keep winning.
He said: "We are fighting with a team quite similar to Liverpool in the past, in the final of the Champions League without losing a game and have been top of the league almost all season.
"It's not in our hands now so it depends on them dropping points but all we can do is Wednesday win again, play the final of the FA Cup and go to Bournemouth - I'd say that is not the best one to go to - and Aston Villa.
"I love to be here again. Finish second again minimum so I love it. I didn't enjoy last season and the moment to fight to qualify for the Champions League was difficult but the Carabao Cup is in our pocket, the FA Cup final at Wembley is the most beautiful day of the season and I love it.
"When you arrive and have the feeling that the job can be done, well done.