The skipper suffered an apparent hamstring injury late into the 2-1 win.
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Howe said afterwards: "We're not sure (of full extent). He is a little bit worried, he's never had problems with his hamstring before, so was it cramp? A muscle problem?
"Feels like more of an injury to me. But let's see and try to stay positive at this moment."
He added: "I just hope we have not lost Bruno, that would be the real negative of the night."