Casemiro, who is also out of the Brazil squad for upcoming international games, has sustained a muscle injury.
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Speaking about the 32-year-old pre-game, manager Erik ten Hag stated to ITV: "It does (affect us) because Casemiro is very experienced and a very important player for us in organization, also on the ball.
He brings composure to the team and he can bring great passes to bring our frontline into great positions, especially with the three with their immense speed.
"You miss, of course, a passer like Casemiro."