Per The Sun, he is set to target Sevilla striker Youssef En-Nesyri and defender Marcos Acuna.
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There are also suggestions that Lopertegui has demanded other signings from the board.
One who may likely leave is Michail Antonio, with the forward now 34 and no longer in the prime of his career.
Acuna is 32, but is younger than Aaron Cresswell by two years and may replace him in the team.