The Dutchman had confirmed that he was rotating the team, given they play Liverpool on Sunday.
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The forward did come on for the eventual 4-3 defeat to the Stamford Bridge club.
Pre-game, Ten Hag told MUTV: "For rotation to keep him and the team fresh through a busy period with another big game on Sunday."
He added to TNT Sports: "We have two big games in three days, we need everyone. We need the bench and lately we have had a strong bench.
"Recently players from the bench have impacted. Mason Mount. It is a huge impact and it is a good impact to have Rashford on the bench."