The midfielder is on the outer of manager Thomas Frank's plans this season and can leave in January.
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Fitness and disciplinary problems have engulfed Bissouma this term, with Frank now focusing on other midfield options for the mid- and long-term.
However, despite the rift, The Sun says Spurs could yet trigger a 12-month extension in Bissouma's deal as it runs down this season.
Spurs are ready to make the move in the event a buyer cannot be found next month. The board has little interest in allowing Bissouma to leave for nothing over the summer.
