The Premier League champions have now lost four consecutive games - a first also for Slot in his managerial career.
The Dutchman said afterwards: "I think as a manager you face constantly challenges. When I just started, you face the challenge of being a new manager and then you need to win games. Then when you do well you go to a bigger club and people are like, 'Oh, let's see how he does over there.'
"Then you go to be the successor of Jürgen Klopp and people say this is the biggest challenge you ever faced. Now we have lost four times in a row and that's also a challenge. So, the life of a football manager is an ongoing challenge. If you win games you want to keep winning, if you lose games you want to start winning again.
"Do we lose confidence? I cannot see it yet, because every single game we've lost, we were able to create in the second half an unbelievable amount of chances. If you look back at all the three games we've lost in the Premier League, if you just put all the highlights (next to) each other, you would say it's hardly possible that they lose this game.
"So if we can keep producing what we are doing and do a few things a little bit better, then there is every reason to expect that we start to win football games again. But I cannot promise you that on Wednesday evening we are again able to create eight, nine or 10 open chances. I hope so, and with the players we have then it will lead in the end to us scoring more goals.
"Then there's of course the part no-one asked about but I can tell you. Apart from the two goals we conceded, we have conceded maybe two or three more chances, but this is the struggle we are having being 1-0 down; then you need to take a bit more risk.
"And then I am even quite positive that we limit the opponent so much to the chances they are creating. Because we do take a lot of risk in the moment; after 55 minutes, I think we had six or seven offensive players on the pitch. That might also maybe not be an excuse but be the reason why the structure in defending a set-piece against (Crystal) Palace and now was not as perfect as we usually are, because normally you play with four, five, six defensive-minded players but at that moment we are on the pitch with seven or eight offensive-minded players.
"That's not an excuse because they should do better, we should do better, but maybe it's not a coincidence that exactly in those moments of time we concede a set-piece."