Wirtz produced his best performance of the season in the World Cup qualifier after his struggles with Liverpool.
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And his national team coach took aim at his Liverpool teammates after Friday's performance.
Nagelsmann said: "Even if he hasn't scored a goal, he's the player who creates the most chances in the Premier League.
"It's not his fault if his team-mates doesn't create them, and the statistic isn't even a third of the truth. He simply has to get used to the league.
"I've seen him feel completely liberated. He knows what he's capable of and how things work. Not everything has always been handed to him - he'll work hard now, too."