Salah will leave Anfield at the end of the season after nine years on Merseyside.
"Yes, this specific kind of player is irreplaceable," said former Reds manager Klopp. "That’s always how it is. There will be a void that somebody will fill. It’s always in our minds how much time, how much space – yeah, how much time do we give to whoever is going to play there in whatever system the manager will play.
"But Mo Salah? I’m not sure there is even another one existing out there. There are other people playing on that wing with different strengths, different qualities but it is the numbers he produces – they are unmatched from that position.
"I don’t know if there was ever any player who had that (from there). You tell him he is a winger or a striker he says: 'no, no, no I am a winger'. The numbers for a winger, ridiculous. For a striker they are pretty much unmatched. That’s how it is. So, if it is impossible, why should you try?"
Klopp added: "I’m not in the role to advise anyone. But just bring players in and play the kind of football which can be successful. That is pretty much everything.
"He is an all-time great. One day we will have a legends team with all these current players in and it will be good fun."