The 29-year-old gifted Fulham their second goal after his botched clearance landed at the fee of Harry Wilson, who passed the ball into an open Tottenham net.
Spurs now have just one win in their las five Premier League games and have tumbled down into 10th as pressure grows on Thomas Frank.
Speaking after the game, Vicario insisted that he will not be bothered by the fans that booed him throughout the game and apologised for the defeat.
"It's part of football. So I am a big man. I am quite older. What can I say!,” he said.
"We cannot be influenced by situations in the stand. Fans have the right to do what they think. It's on us to try to stay more calm and focus on ourselves and what we want to do. We know what our strengths are and we are lacking a bit in composure. Its a bad defeat tonight and tough to accept.
"We would like to go up in the results and to lead in the game so we don't have to chase it. But today was this scenario. We had 90 minutes to turn around the result. But we missed a little bit of calmness and composure in trying to score the goals.
"It is what it is. We apologise for the defat. It's painful."