Gopaladesikan joins from Atalanta and will report to the sporting director, who is yet to be appointed.
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He said: "I'm delighted and honoured to be joining Newcastle United as Technical Director.
"Throughout my career, I've had the privilege of working with clubs that have deeply passionate fanbases, and Newcastle stands out for its unique connection between the team, the city and its supporters.
"I'm excited to work alongside the club's talented staff to identify what helps give us a competitive edge.
"Most of all, I'm looking forward to experiencing the incredible matchday atmosphere at St. James' Park and being part of this proud football family and community."