The winger suffered a hamstring injury in the Europa League quarterfinal win against Porto last week.
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Hudson-Odoi was ruled out of Sunday's victory over Burnley, though manager Vitor Pereira offered an upbeat update in the aftermath.
But the Daily Mail says inside the club, there is a belief the winger won't be seen again this season.
This season, the 25 year-old attacker has made 43 appearances for Forest, with aa record of 19 goals and 10 assists.