Mbappe is also a former Monaco player and Squillaci spoke to Marca ahead of their Champions League clash.
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He said, "You guys are very demanding there. He's already doing something incredible at Real Madrid, but he's going to make history at the club.
"It's true that the team isn't doing well right now and that Kylian alone can't win, but Real Madrid is a war machine and they're going to come back."
Meanwhile, Paul Pogba isn't fit to make the clash for Monaco and Squillaci added: "I know him, he's a great person, and I hope he can come back.
"Monaco needs him because he's like a Formula 1 car, but for it to work, he needs to play regularly, have consistency, and he's finding that difficult. I hope he gets there."