Victory for Barca at Osasuna could confirm them as LaLiga champions should other results go their way.
And for Garcia, the 24 year-old could also clinch the Zamora Trophy as the best performing goalkeeper in LaLiga this season.
The 24-year-old already has the best record in LaLiga: he has conceded 19 goals in 27 matches, averaging 0.70 goals per game.
However, the rules of the award stipulate that goalkeepers must play a minimum of 60 minutes across 28 matches to be included in the ranking.
A knee injury this season has seen Garcia not yet reach the required minutes - though that will change against Osasuna. This will be his 28th appearance in the competition.
García, therefore, is all set to win the Zamora Trophy in his first season with Barcelona, having joined last summer from Espanyol.