St James' Park hosts Barcelona for the second time in six months on Tuesday night as The Magpies seek to do the impossible and knock the Spanish giants out of the Champions League.
Manager Eddie Howe described the match as “the biggest in the club’s history” as the side look to secure progress to the quarter-finals of the Champions League for the first time.
Having both scored and conceded in each of their last 12 games across all competitions, Newcastle will be full of confidence heading into the clash which is the toughest of the season so far.
Howe will be without 4 players ahead of the game, with Emil Krafth (knee) and Fabian Schar (ankle) both out in defence as the likes of Lewis Hall, Joe Willock and Malick Thiaw step in at the back.
Meanwhile, Lewis Miley (thigh) and Bruno Guimaraes (thigh) are also out with Howe proving an update on the Newcastle captain at the end of the last month.
“I have had some good contact with Bruno. He seems very positive with his injury and how he feels. He has done a lot of work.
“We hope that he can come back and give us a push at the back end of the season. We have to treat his (hamstring) injury carefully.”
Tino Livramento returns to the side however whilst Jacob Ramsey is also back after he missed the Manchester City match due to suspension after being controversially shown two yellow cards in the previous game against Manchester United.