The Liverpool legend joined the Super Lig side after leaving the Premier League, where he scored 257 goals.
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Salah marked his presence with a brace and the Super Eagle claims defenders cannot afford even the slightest lapse against the Egyptian forward.
“Every player who plays against Salah needs to be very prepared,” Nwaiwu told Haber61.
“As a defender, I would like to play against Salah. If I’m going to play against him, I need to be 100% ready and completely focused. Because Salah is not a player you can easily take out of the game. He has very high quality.”
The 34-year-old signed a two-year contract worth £280,000 per week and has already made three appearances for the Turkish club this season.