The 31-year-old joins Orient after playing 47 times for QPR across two spells, and has signed a two-year contract, per BBC sport.
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The Jamaica international has plenty of experience, having played for the likes of Newcastle United where he made 171 appearances.
The deal also includes an option to extend for a further year.
Speaking to the Leyton Orient website, head coach Richie Wellens said: "His footballing ability speaks for itself.
"He's played at a high level for the majority of his career and understands what it takes to win games."