Howe said: "I could change things around. It's nice to have those options. I need to look at those players individually, as all their injuries are different. If I didn't it would be foolish of me. They are vital players, just their presence is important."
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On Newcastle's quest for Europe, he said: "It's a massive fixture for both teams. It's coming to the end of a long season, we are desperate to do well in games and we are desperate to finish as high up as possible.
"We know the European competition is there but it can still be a long way away to get the result we want."