The Spaniard is being mentioned as a replacement for Stefano Pioli next season.
La Gazzetta dello Sport reports that Thursday's exit from the Europa League has convinced the club's management to seek a new head coach.
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Lopetegui has emerged as a favourite for the post.
The Spaniard is favoured ahead of other candidates such as Paulo Fonseca, Christophe Galtier and Marcelo Gallardo.