TalkSPORT says Spurs have put Bissouma up for sale this summer.
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The midfielder has attracted interest from Roma, though could also move within the Premier League.
West Ham are now making a move for Bissouma after allowing Edson Alvarez to leave on-loan for Fenerbahce.
Spurs are said to be seeking £20m to sell Bissouma before next week's transfer deadline.