Tottenham are now just six points from the relegation zone and are still searching for their first league win of 2026 and enter the clash with 10 injuries as well as a suspension to captain Romero.
Newcastle will take confidence from this as they aim to bounce back from their third straight loss in all competitions to Brentford.
Howe’s side have won five of their last seven Premier League matches against Spurs but drew 2-2 last time out in what was a tough test for both sides.
His side enters the game with a number of knock with Emil Krafth (knee), Valentino Livramento (thigh) and Fabian Schar (ankle) all out in defence.
Further up the pitch, The Magpies will be without Lewis Miley (thigh), Anthony Gordon (thigh) and Joelinton (groin).
Thankfully Nick Woltemade and Yoane Wissa are both fit to start the game despite criticism in recent weeks and the pair should earn minutes once again in front of the home crowd who will expect nothing but a win.
Wissa has scored just once in his last 11 appearances and will hope to build up his confidence against an injury ridden Tottenham side who will struggle to avoid relegation this season.