The Magpies announced in September last year that Eales would be standing down for health reasons and on Thursday afternoon have revealed that the club have appointed Hopkinson as his successor.
A great honour for Hopkinson
Speaking to the club website, Hopkinson says he cannot get wait to get started with the Premier League side who he says he greatly admires.
"I am incredibly honoured to join Newcastle United at such an exciting time in the club's history.
"This club represents something truly special. It has extraordinary history and heritage, incredibly passionate supporters, and ownership, players and staff who are committed to excellence.
"Having worked with iconic teams across different countries, I understand what it takes to build sustainable success at the highest levels of global sport.
"I greatly admire what has been achieved by the club so far, and I am excited and motivated by what is ahead as we strive to position Newcastle United among the world's elite clubs."
A warm welcome
Hopkinson is due to start work on Friday, having arrived in the UK and having received Premier League approval as he picks up the reigns. The 54-year-old brings a wealth of executive-level experience and chairman, Yasir Al-Rumayyan welcomed him with open arms.
"David is an outstanding executive whose track record across global sport and entertainment speaks for itself.
"His experience and strategic capabilities will be invaluable as we continue to build on the club's presence locally and grow it globally on and off the pitch.
"David's leadership will be critical as we build upon what we have already achieved since the acquisition towards an exciting future and sustainable success.
"I would like to personally thank Darren Eales for his exceptional work and leadership, as well as his friendship, over the last three years."