Amorim will be hoping United can earn their first back-to-back Premier League wins since he took over with a victory over Liverpool at Anfield on Sunday (October 19).
Despite their poor start to the season, a victory would take United just two points behind the current champions in the league table.
De Ligt, 26, has played every minute of the club’s Premier League campaign so far, and recently addressed his relationship with Amorim.
In an interview with the Telegraph, the Dutchman said: “I have a good relationship with him (Amorim) because of this (Amorim’s straight-talking style), because he’s quite direct and I am quite direct with him.
“It’s about honesty and also in honesty you can say things that are sometimes not so good and you accept that also, you know, because it’s the only way. Communication and clarity is the most important thing in a team.
“We’re improving as a team. In modern football even if you play a back four almost all teams play by building with three defenders. And we do often defend with four defenders.”
When asked whether there is too much focus on the manager, he added: “I don’t know. I don’t read all the things they say about the manager. But I think every player here and the staff feels that the pressure is on us.”