The 23-year-old has been limited to just four appearances across all competitions this season as he contends with an ongoing groin injury.
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Palmer was forced out of the 5-1 Premier League win over West Ham just minutes before kick-off and was then rushed back for the 2-1 defeat to Man United.
According to a report from BBC Sport, Palmer is now expected to be sidelined until November, meaning he will likely miss games against Nottingham Forest, Ajax, Sunderland and Wolves.
England boss Thomas Tuchel opted against calling Palmer up to his latest England squad to face Wales and Latvia as he continues his mission to return to full fitness.