The midfielder has been plagued by numerous injuries in recent weeks. Suffering from a shoulder injury after a bad fall during the match against Nottingham Forest in September, Odegaard suffered yet another setback this Saturday.
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At home to West Ham, the Gunners' number 8 suffered a knee injury around the 20th minute. He decided to continue playing, but ultimately realized he couldn't continue and instead made way for Martin Zubimendi.
The injury threatens to be a heavy blow for both Arsenal and Norway.
The Norwegians enter next week's World Cup qualifiers needing to get back on track after a stumbling start.