The teen featured in Barca's Champions League defeat to PSG in midweek, but is out of Spain's squad due to injury.
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A Barca statement read on Friday: "The groin problem for Lamine Yamal has returned following the game against PSG.
"The player will miss (Sunday's) game against Sevilla and his recovery time is estimated at 2-3 weeks."
Spain coach Luis de la Fuente has been criticised by Barca counterpart Hansi Flick over his management of Yamal for the past 12 months.