It will be the third season in a row the two giants have met in a knockout round.
Guardiola said: "Yeah, we don't have another option. It looks like a little bit of a tradition, three years in a row.
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"The kings of the competition. It is what it is. Hopefully we can arrive in a good moment.
"Few weeks before the first game."
He also said: "For us it's a little new, for Madrid it's not special to play in the quarter-finals of the Champions League. They've been quite consistent many times.
"In these stages you play the best teams in the world. It is what it is. I don't pay much attention, all opponents would be tough. I said many times, Premier League, Bundesliga, La Liga...difficult with a lot of games."