Chelsea striker Lukaku has spent the season on-loan from Chelsea, while Doku has impressed in his first season with Manchester City.
Tedesco said: "Lukaku has enormous importance for us, even off the pitch. On the pitch the goals speak for him, but not only that, because he knows very well when he has to play with his back to the goal or turn around to look for goals alone.
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"Against Doku it is instead very difficult to defend, I think no defender wants to be in a match with him. Jrmy is capable of changing the game at any moment.
"His dynamism can give us a lot."