La Gazzetta dello Sport says United have decided to place Zirkzee on their transfer-list ahead of the January market.
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Offers are being invited and Roma director Ricky Massara will soon make an approach to kickoff negotiations over a fee for the former Bologna striker.
Zirkzee is Roma's top choice in terms of a centre-forward signing over the winter transfer window. But the buying won't end there, with Massara also seeking a new winger addition.
High on the shopping list is Franculino Dju, of tomorrow night's Europa League opponents FC Midtjylland, with Massara aiming to make a serious scouting check on the attacker on Thursday.