The 27-year-old has been in talks with AC Milan for the past few days with the Serie A club in need of a replacement for Theo Hernandez, who joined Saudi club Al-Hilal.
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According to Fabrizio Romano, an agreement has now been reached between Brighton and Milan for the transfer Estupinan.
It’s understood the fee will be €17 million plus €2m in add-ons, for the Ecuador international who made 36 appearances across all competitions last season.
Brighton have already managed to sign a replacement for Estupinan, signing Maxim De Cuyper from Club Brugge earlier in the summer.