The England youth international defender's move is being viewed as a major coup by Newcastle.
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Moore made his Liverpool U18 debut as a 15 year-old and has also captained England at U16 level.
Academy Director Steve Harper said: “Isaac joins us with a strong pedigree and a maturity beyond his years.
“The leadership qualities he has displayed to date speak volumes about his character, and we’re excited to help him continue developing both as a player and a person.
“He’s a driven individual who fits the values of our Academy perfectly.”
“Isaac’s addition to the Academy reflects the continued excellence of our recruitment team, whose efforts remain integral to our long-term strategy.”