The former Spain international isn't in the plans of Tottenham manager Thomas Frank and been encouraged to find himself a new club.
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Transfer expert Fabrizio Romano is reporting Reguilon's management team is now in talks with Inter Miami about a move to the USA in time for the 2026 MLS season.
At Inter Miami, former Real Madrid and Sevilla fullback Reguilon would find former Barcelona trio Leo Messi, Luis Suarez and Jordi Alba.
Inter Miami coach Javier Mascherano is also an ex-Barca star.