The Spaniard sustained a complicated ankle injury in their 2-0 midweek win over Brentford. He had to be substituted after landing awkwardly
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Initial reports suggested he could be sidelined for six to eight weeks, pending further tests.
The setback leaves Mikel Arteta with a mounting centre-back crisis, as Gabriel Magalhaes remains out with a thigh injury and William Saliba is still recovering, though reportedly close to a return.
Mosquera had been providing stability alongside Piero Hincapie, but his absence adds to Arsenal’s defensive worries ahead of crucial fixtures, including a trip to third-placed Aston Villa and a Champions League clash with Club Brugge.