Southampton have been rocked by fitness news ahead of next week's relegation six-pointer away at West Ham.
The Saints have to defeat the Hammers if they are to push themselves beyond the bottom of the Premier League table.
With so much at stake for boss Ruben Selles, he will be disappointed to learn about an issue for a key forward.
Forward Che Adams is a major doubt for the contest, as he has pulled out of the Scotland squad.
Adams will not be in the team to take on Spain in the week, with the 26-year-old unable to complete the Scots' win over Cyprus at the weekend.
Saints fans will be hoping he can recover in time to at least make the bench against West Ham.