The two teams meet again so soon after Wolves impressive FA Cup quarter final win over United on the same ground.
But the Portuguese knows that his side faces a fantastic team that will give everything to get some payback for that result.
"Every game is a new challenge, especially when you're going to face a fantastic team," he said in his press conference.
"We have to really compete well, be organised and be focused on our task.
"They will require a lot of effort. That night was special for us, for our fans, but this is a new challenge in a different competition. We have to be ready for it."