The Blues don't have to play again until Monday night, and if Spurs manage to pick three up points at London Stadium, they will find themselves just a point behind the leaders.
"It is good to go first – we have got to try to drop the gap to one point and see what happens," said Kane.
"We knew what it was like last year with Leicester playing before us. It is difficult. It is good to try to play first and try to put that pressure on, so it will be good to play on Friday night. It is another tough game away from home but hopefully we can get that win, put that pressure on and wait and see."
"We could end up on 89 [points] and still not win the league," Kane said. "That would be disappointing. We have got four games in front of us and we feel like we can win all four. We feel we can beat anyone. We have just got to learn from what happened last year and we feel like we are doing that."
"This year is more difficult," he said. "We finished 2015 eight points more than City. I'm not sure that will be the case with Tottenham. I'm sure they won't give up until the end. It's hard.
"We win, Tottenham win. We try to win again and they win again. It's close. We'll see if they drop some points. They also have some difficult games at home and away. Everything is open until the end."