Spurs are second heading into the international break after a slim 1-0 victory over West Bromwich Albion.
And Neville believes it would make a great story for Mourinho to end Tottenham's 59-year wait for a top-flight title.
"I said a couple weeks ago on Monday Night Football that Spurs couldn't win the league, and I still don't think they can," he told The Gary Neville Podcast.
"He's got the forward players to do it. You think of the strike force and the goal - it's incredible."