It's a battle between the Premier League's top two at the Etihad Stadium, with a victory for City extending their lead at the summit to 13 points.
De Bruyne said: “It is exciting. I think you always want to play in the biggest games.
“We had so many battles over the years where we have won and they have won a couple of games in the Premier League and Champions League.
“You always want to be on top and that is what we want to do tomorrow.
“It is a big game. They have been playing really well lately. I saw the Liverpool game (2-2 Premier League draw) and a little bit of the first Tottenham game (2-0 Carabao Cup win), so they have been in a good rhythm.
“I expect them to give us a big test."
He said: “(Romelu Lukaku) is a massive threat. I have known Rom since I was 15 or 16 years-old and he has always been a good friend of mine.
“He scores a lot of goals, he is very dangerous, so I know we are going to have a handful with him.
“Hopefully we can keep him quiet for this game, then after he can play as good as he wants!
“(Thomas Tuchel) has done great. He came in when Chelsea was struggling a little bit, but he made the team very solid, he found a system that works for them and that worked before with (Antonio) Conte also.
“It is very hard to break them down and offensively they are very strong, they have a lot of great attacking options. It always makes a big test for us to beat them."
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