Tottenham take a three goal lead from the round 16 first leg but Reus claims the famous yellow wall of noise in Dortmund can still blow Mauricio Pochettino's men away.
Dortmund midfielder Reus said: “We have played many games in this stadium where we've written history and we are in position to achieve the impossible.
“It is important to believe in ourselves, and give a great performance. We need to find the right balance between defence and attack. We need to reach our peak, and score the goals in the right moment. But we believe in ourselves."
Reus added: "It's important to be positive and really work hard and watch all the games and learn from mistakes. It's very important to stop the mistakes because we know we can always score in attack.
“We have to be stronger, come out stronger; have the right mentality. We've shown that, I think we'll come out of this situation."