Suarez missed the first meeting between the two teams in November after contracting coronavirus while on international duty with Uruguay.
Koeman was tasked with telling Suarez he didn't have a future at the club last summer, although the decision was effectively made for him.
Asked about Suarez's return this weekend, the Dutch coach said: "It will probably be strange for Suarez and for our players, he was here for many years.
"But we are professionals. Everyone will give there all to win the game. There's no need to go round in circles on this. We have to focus on him but also on Atletico's other players."