Kolo and Yaya Toure have been told they cannot play in the game by the Ivory Coast FA.
Already without Gareth Barry through suspension, with Mario Balotelli deemed "unlikely" to recover from an ankle injury sustained in training last week and Samir Nasri trying to shake off an illness, Mancini always knew his resources would be depleted.
"For Sunday we have 17 players," he said. "I don't think we will have 18.
"Gareth is suspended, Mario is injured. Samir was better on Wednesday but I don't know."