The 26-year old striker suffered a broken leg against Blackburn Rovers in the FA Cup at the beginning of the year but managed to play 64 minutes just over 10 months later as the R’s drew 1-1 with the team he sustained the injury against.
Mackie thanked manager Neil Warnock whilst admitting it was a relief to be back out on the pitch for the West London club.
"It felt brilliant. I've worked really hard and I was delighted to be back out there with the boys,” he told the club’s official website.
"It was a massive day for me. It was a bit ironic that it came against Blackburn. I want to thank everybody that helped me along the way.
"I got some nice comments from people at Blackburn, too. I can't praise their medical staff enough for their help when I got injured in January.
"The gaffer's been quality with me since I've been out injured and has shown a lot of faith in me.
"He's been willing me to get back. I thought I did well on Saturday and with games I'll get sharper and back to my best.
"I've been doing a lot of conditioning work with the fitness staff. Obviously it is a different tempo (playing first team football in the Premier League) but I'll get used to it and I'm looking forward to the massive games that are coming up.
"I'm back now and I'm going to improve with every game."