Kane, the golden boot winner at the World Cup, has question marks over burning himself out even at this early stage of the campaign.
Both Spurs and England rely heavily on the 25-year-old but Trippier is confident the striker can keep producing.
"I'm not concerned, he's first in and last out [of training]. He recovers well and everybody knows Harry's a top professional," Trippier said.
"I can't see him slowing down, you've seen his work-rate in the games we've played this season. He's as fit as anything."