Tottenham see Inter Milan veteran Diego Godin as a potential replacement for Jan Vertonghen.
Vertonghen is set to leave when his Spurs deal expires in June.
Mundo Deportivo says Tottenham have identified Godin as a "serious" transfer target.
Tottenham are looking for a central defender to add experience and quality to their backline and believe the 34-year-old Uruguayan can do this.
The centre-back joined Inter on a free transfer last summer after running down his contract with Atletico Madrid.
However, Godin has struggled to adapt to Antonio Conte's system.
As a result, he could be shown the exit this summer for around £7million, despite being under contract until 2022.