Tottenham chief Fabio Paratici is targeting Serie A to boost their defensive options.
Spurs boss Antonio Conte is eager to strenghten the squad in January, with a focus on the defence.
Conte wants both players through the door in January as he isn't convinced by the defensive group he has inherited.
De Ligt's contract with Juventus extends to 2024 while De Vrij's contract with Inter runs to 2023.
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